Definition of AFFECTION in the Definitions.net dictionary. Meaning of AFFECTION . What does AFFECTION mean ? Information and translations of AFFECTION in the most comprehensive dictionary definitions resource on the web. Affection is a vital element of human relationships, providing an emotional foundation that supports well-being and mental health. Affection definition : fond attachment, devotion, or love.. See examples of AFFECTION used in a sentence. Affection is a tender feeling toward another, a feeling or emotion, or a diseased condition. Find out the origin, usage, and translations of the word affection in different contexts and languages.