The meaning of commerce, as a fundamental concept in business and economics, encompasses the exchange of goods, services, and financial transactions between individuals, businesses, or nations. Define commerce. commerce synonyms, commerce pronunciation, commerce translation, English dictionary definition of commerce. n. 1. The buying and selling of goods, especially on a large scale, as between cities or nations. See Synonyms at business. 2. Intellectual exchange or... Guide to what is Commerce and its meaning. Here we explain how commerce in business works, its types along with examples. Commerce : What is meant by Commerce? Learn about Commerce in detail, including its explanation, and significance in Economy on The Economic Times.