Constipation is difficulty passing stools due to poor diet and lack of exercise. Over-the-counter medications such as polyethylene glycol, bisacodyl, or senna are better choices than prescription medicines. Constipation medications are available in over-the-counter and prescription versions. Find out which options might work well for you. Find out what kind of prescription and over-the-counter medicine can help treat chronic constipation. Find the various medicines available for treating constipation and how to use them. Learn about the effectiveness of these medications.