Something that is designed to work smoothly with the human body is designed to be ergonomic . If your fingers ache after using the computer, you may need an ergonomic keyboard. Or you could play fewer video games. Ergonomics (HFE) is the scientific discipline and profession that optimizes human well-being and system performance by understanding human-system interactions. It covers physical, cognitive, organizational, and sociotechnical aspects of work and design, and applies a holistic, participatory, and user-centric approach. Ergonomics can roughly be defined as the study of people in their working environment. More specifically, an ergonomist (pronounced like economist) designs or modifies the work to fit the worker, not the other way around. Ergonomics definition : the study of people's interaction with their work environment, especially when concerned with making that environment physically, mentally, and organizationally safe, comfortable, and efficient.. See examples of ERGONOMICS used in a sentence.