Summary: It has been 10 years since human metapneumovirus (HMPV) was identified as a causative agent of respiratory illness in humans. Since then, numerous studies have contributed to a substantial body of knowledge on many aspects of HMPV. This ... In this review, we highlight recent advancements in treatment, adult infections, and the structural features of known antigenic sites on the HMPV proteins. Etiology, Treatment, Acute Respiratory Infection, Clinical Characteristics, Epidemiology, Human Metapneumovirus (HMPV) Abstract Human metapneumovirus (hMPV) is an emerging respiratory pathogen with a significant global health impact, especially in children, the elderly, and immunocompromised individuals. Since its identification in 2001, hMPV has been recognized as a major contributor to acute respiratory infections (ARIs), ranging from mild upper respiratory tract infections to severe lower respiratory tract illnesses such as bronchiolitis and pneumonia. This review provides a detailed overview of hMPV ... Human metapneumovirus (HMPV) is a virus that causes acute respiratory infection, mostly in children, the elderly, and people with weak immunity. Its symptoms resemble a common cold but can cause respiratory infections like pneumonia and bronchiolitis.