Natural immunoglobulin M (IgM) antibodies are pentameric or hexameric macro-immunoglobulins and have been highly conserved during evolution. IgMs are initially expressed during B cell ontogeny and are the first antibodies secreted following exposure to foreign antigens. What is Immunoglobulin M (IgM Antibody)? Immunoglobulin M (IgM) is a crucial component of the immune response to exogenous pathogens. It is one of several isotypes of antibodies, also called immunoglobulins, produced by vertebrates. IgM is the first antibody produced during an immune response and functions as an antigen receptor on B cells. Mature B lymphocytes express IgM as a transmembrane antigen receptor at rest, constituting a portion of the B-cell receptor (BCR). B cell activation ... It stands for Immunoglobulin M, the first antibody our body produces when exposed to a new antigen. It is secreted by early B cells and exists primarily in the blood and lymphatic fluid. ICEGATE (Indian Customs EDI Gateway) is an e-commerce portal of the Indian Customs which offers services such as e-filing of Bills of Entry (Import Goods Declaration);Shipping Bills (Export Goods Declaration); and EDI between Customs and its Trade Partners for IGM, EGM, Customs Duty Payment and Drawback Disbursal through electronic messages.
