The meaning of INDIGENOUS is produced, growing, living, or occurring natively or naturally in a particular region or environment. How to use indigenous in a sentence. Did you know? Synonym Discussion of Indigenous . There are five meanings listed in OED's entry for the word indigenous . See ‘ Meaning & use’ for definitions, usage, and quotation evidence. Indigenous definition : originating in and characteristic of a particular region or country; native (often followed byto ).. See examples of INDIGENOUS used in a sentence. INDIGENOUS definition : 1. used to refer to the people who originally lived in a place, rather than people who moved there…. Learn more.