Pemphigus is an uncommon autoimmune blistering disease, mediated by antibodies directed against desmosomal adhesion proteins (most particularly desmogleins 1 and 3) that are responsible for maintaining integrity of the epidermis. This article will discuss its epidemiology, pathogenesis, clinical variants and approaches to treatment. Pemphigus has three major variants, which are classified depending on the basis of the clini-cal, histological features, immunofluorescence staining patern and autoantibody profile of the disease including pemphigus vulgaris (PV), pemphigus foliaceus (PF), and paraneoplastic pemphigus (PNP), which all have further subtypes. Pemphigus is a group of rare skin disorders that cause blisters and sores on the skin or mucous membranes, such as in the mouth or on the genitals. It's most common in people middle-aged or older. What is Pemphigus Vulgaris? Pemphigus Vulgaris is an autoimmune disease that primarily affects the skin and mucous membranes. In this condition, the body's immune system mistakenly attacks proteins in the skin called desmogleins, which are essential for holding skin cells together. This leads to the formation of blisters and erosions, causing significant discomfort and increasing the risk of infections.
