Polymyxins comprise a class of antibiotics targeting gram-negative bacterial infections. Polymyxin B and Polymyxin E (colistin) are the two drugs within this antibiotic class used primarily in clinical practice. Polymyxin B is an antibiotic used to treat bacterial infections. It can cause kidney and nerve problems, and interact with other drugs. Learn about its dosage, side effects, and precautions. Easy-to-read patient leaflet for Polymyxin B. Includes indications, proper use, special instructions, precautions, and possible side effects. Polymyxin B for Injection is one of a group of basic polypeptide antibiotics derived from B polymyxa (B aerosporous). Polymyxin B sulfate is the sulfate salt of Polymyxins B 1 and B 2, which are produced by the growth of Bacillus polymyxa (Prazmowski) Migula (Fam.Bacillacea).