Prognosis A prognosis is the likely outcome of a disease, injury or illness. It determines how likely you are to recover and predicts how your condition is likely to unfold over time. Healthcare providers communicate prognoses to help people plan treatments and make life decisions related to their health. 2 meanings : 1. medicine a. a prediction of the course or outcome of a disease or disorder b. the chances of recovery from a.... Click for more definitions. PROGNOSIS definition : 1. a doctor's judgment of the likely or expected development of a disease or of the chances of…. Learn more. PROGNOSIS meaning : 1. a doctor's judgment of the likely or expected development of a disease or of the chances of…. Learn more.