Pus cells in urine, or pyuria, are a sign of infection or inflammation in the urinary tract. Learn about the causes, symptoms, and treatment of pus cells in urine, and how to test for them with a urinalysis. Pus cells in urine, or pyuria, is a condition that indicates a high number of white blood cells in the urine. It can be a sign of infection, inflammation, or other underlying diseases. Learn about the causes, symptoms, diagnosis, treatment, and prevention of pyuria. Pus cells are white blood cells (WBCs) that help your body fight infections. When they’re found in your urine, it usually means your immune system is responding to something going wrong in your urinary tract — like an infection or inflammation. This condition is medically known as pyuria. In small numbers, pus cells in urine can be harmless. But a high count? That often means there’s a bigger issue that needs your attention. Discover what pus cells in urine mean, common causes, expert insights, and practical steps for dealing with elevated counts.