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There are eight blood types, divided into four categories: A, B, AB, and O, and whether Rh positive or negative. These types are determined by antigens on red blood cells. Learn what this means. Not all blood is alike. Learn about blood typing and the rarest and most common types of blood and how they can impact your blood donation. Rare blood groups in India are a lesser-known but critical aspect of our healthcare system. While most of us are familiar with common blood types like A+, B+, or O-, there are unique and uncommon blood groups that occur in only a tiny fraction of the population. The rarest blood group in the world is Rh-null. Learn about its unique characteristics, compatibility challenges, and the medical implications.