Sitagliptin is used in the treatment of Type 2 diabetes mellitus. View Sitagliptin ’s uses, side-effects, drug interactions, expert advice and user FAQs only on 1mg .com. Find out how sitagliptin treats type 2 diabetes , and how to take it. NHS medicines information on sitagliptin – what it's used for, side effects, dosage and who can take it. Sitagliptin M 50mg/500mg Tablet is a combination of two medicines that control high blood sugar levels in people with type 2 diabetes mellitus. This helps prevent serious complications of diabetes, such as kidney damage and blindness and may reduce your chances of having a heart attack or stroke. Sitagliptin is used alone or together with other medicines (eg, insulin, glimepiride, metformin, or pioglitazone) and with proper diet and exercise to treat high blood sugar levels caused by type 2 diabetes.