Trihexyphenidyl is used in Parkinson's disease and drug induced abnormal movements. Trihexyphenidyl is an anticholinergic medication. It works by decreasing the activity of a chemical messenger (acetylcholine) in the brain. This improves muscle control and reduces stiffness in Parkinson's disease. Find out about Trihexyphenidyl benefits, side effects, price, dose, how to use Trihexyphenidyl, interactions and contraindications Trihexyphenidyl (THP, benzhexol, trihex, marketed as Artane and others) is an antispasmodic drug used to treat stiffness, tremors, spasms, and poor muscle control. Trihexyphenidyl/benzhexol is an anticholinergic medication used for the treatment of tremors, spasms, stiffness, and weak muscle control seen in patients with Parkinson disease.