Wifey definition: an informal word for wife. See examples of WIFEY used in a sentence. Sandra Otterson, also known as " Wifey ," rose to fame in the adult entertainment industry with her husband, Kevin Otterson. Their website, " Wifey 's World," became a pioneering success in amateur adult content, inspiring others to explore this niche. wifey definition: affectionate term for a girlfriend. Check meanings, examples, usage tips, pronunciation, domains, related words. Wifey refers to an informal term used affectionately to describe a man's wife or long-term female partner. e.g., He planned a surprise vacation for his wifey on their anniversary.