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Adapalene (brand name Differin) is a type of topical retinoid used to treat acne and reduce the appearance of fine lines and wrinkles. Adapalene is the only FDA-approved topical retinoid available over-the-counter. Find out if Adapalene is the right acne treatment for you. Adapalene is an Antiacne Agent belonging to pharmacology class of Retinoic Acid Derivative Adapalene can be used in the treatment of Acne Vulgaris. Adapalene is Minimal systemic absorption and get excreted Via bile with terminal elimination half-life of 7-51 hours The common side effects associated ... Adapalene is used to treat acne. It may decrease the number and severity of acne pimples and promote quick healing of pimples that do develop. Adapalene belongs to a class of medications called retinoids. Learn about side effects, dosages, drug interactions, and more.