Explore the history, structure, antimicrobial activity, mechanism of action, and overcoming resistance of aminoglycosides in this guide. Aminoglycosides - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD Manuals - Medical Professional Version. Aminoglycosides (gentamicin, tobramycin and amikacin) are highly effective parenteral drugs commonly used as initial empirical therapy of serious Gram-negative infections. They have rapid bactericidal activity and relatively low rates of resistance ...

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