Anti-arrhythmic drugs play a vital role in managing these abnormal heart rhythms and restoring the heart's regular rhythm. Antiarrhythmic drugs are used to treat various types of abnormal heart rhythms (arrhythmias). They are classified into four main classes (Class I, II, III and Most antiarrhythmic drugs are grouped into 4 main classes (Vaughan Williams classification) based on their dominant cellular electrophysiologic effect, with subsequent updates to the classification system for newer medications (see table Antiarrhythmic Drugs (Vaughan Williams Classification)) (1, 2). Learn about antiarrhythmic agents, a group of medicines that treat abnormal heart rhythms. Find out the types, causes, and classes of arrhythmias and compare antiarrhythmic drugs.