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The most common cause of ascites is: Liver disease Less common causes of ascites include disorders unrelated to the liver, such as cancer, heart failure, kidney failure, inflammation of the pancreas (pancreatitis), and tuberculosis affecting the lining of the abdomen. Ascites tends to occur in long-standing (chronic) rather than in short-lived (acute) liver disorders. It most commonly results from: Portal hypertension—high pressure in the portal vein (the large vein that brings blood from ... Ascites is a buildup of fluid in the abdomen. It can happen when the liver is not working properly. Fluid fills the space between the organs and the abdominal lining, leading to swelling and pain. Ascites is the abnormal build-up of fluid in the abdomen, often caused by liver cirrhosis, cancer, heart failure or other conditions. Learn about the symptoms, complications, diagnostic methods and treatment options for ascites from this comprehensive article. The medical definition of ascites is an abnormal accumulation of fluid within the (peritoneal) cavity. Ascites are caused by a variety of diseases and conditions, for example, cirrhosis of the liver, cancer within the abdomen, congestive heart failure, and tuberculosis.