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Budd-Chiari syndrome is an uncommon disorder defined as hepatic venous outflow obstruction, thrombotic or otherwise, not due to pericardial disease, cardiac disease, or sinusoidal obstruction syndrome (hepatic veno-occlusive disease). Primary Budd-Chiari syndrome is a particularly rare (diagnosed in … Budd Chiari syndrome definition Budd-Chiari syndrome is a rare liver condition that is defined as, obstruction to the outflow of blood in hepatic veins at any point, ranging from the small hepatic vein to the junction of the right atrium (heart chamber) and inferior vena cava (largest vein in the body carrying deoxygenated blood). Recent advances have changed our understanding of this disease, as well as the outcomes. In this review, we confine our discussion to primary BCS. Budd-Chiari syndrome is an uncommon condition induced by thrombotic or nonthrombotic obstruction of the hepatic venous outflow and is characterized by hepatomegaly, ascites, and abdominal pain. [1] See the image below.