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Diagnosis, the process of determining the nature of a disease or disorder and distinguishing it from other possible conditions. The term comes from the Greek gnosis, meaning knowledge. The meaning of DIAGNOSIS is the art or act of identifying a disease from its signs and symptoms. How to use diagnosis in a sentence. We explain what diagnosis means and in what areas this term is used. Medical, social, business, differential diagnosis and more. n. the process of determining the nature of a disorder by considering the patient’s signs and symptoms, medical background, and – when necessary – results of laboratory tests and X-ray examinations. Unlike therapeutic procedures, diagnostic processes usually do not directly benefit the patient in terms of treatment. See also differential diagnosis, prenatal diagnosis. Compare prognosis. —diagnostic adj.