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Guillain-Barré syndrome (GBS) is a rare condition that causes sudden numbness and muscle weakness that can affect most of your body. It happens when your immune system responds abnormally and attacks your peripheral nerves. Most people make a full recovery from GBS with treatment and rehabilitation. What is Guillain-Barré syndrome? In Guillain-Barré syndrome (GBS), the body's immune system attacks part of the peripheral nervous system. The syndrome can affect the nerves that control muscle movement as well as those that transmit pain, temperature and touch sensations. Guillain-Barré Syndrome (GBS) is a rare autoimmune disorder affecting the peripheral nervous system. Explore the three phases of GBS, symptoms, types, causes, complications, and treatment options. Guillain-Barre (gee-YAH-buh-RAY) syndrome is a condition in which the body's immune system attacks the nerves. It can cause weakness, numbness or paralysis. Weakness and tingling in the hands and feet are usually the first symptoms. These sensations can quickly spread and may lead to paralysis.