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IgA nephropathy is a kidney disease that can cause long-term kidney damage. Learn about its causes, symptoms, diagnosis, and treatment options. Immunoglobulin A (IgA) nephropathy (also known as Berger disease) was first described by Berger and Hinglais in 1968. IgA nephropathy is characterized by predominant IgA deposition in the glomerular mesangium. IgA nephropathy is a kidney disease caused by abnormal antibodies that damage the glomeruli. Learn about the symptoms, diagnosis, treatment and outlook of this condition from Cleveland Clinic experts. Iga Nephropathy: Understanding a Common Kidney Condition Introduction IgA nephropathy, also known as Berger's disease, is a kidney disorder that occurs when immunoglobulin A (IgA) deposits build up in the kidneys, leading to inflammation and damage. This condition is significant because it is one of the most common causes of kidney disease worldwide, particularly in young adults and adolescents. Understanding IgA nephropathy is crucial for early diagnosis and effective management, which can ...