Yes, inverted nipples can be a sign of breast cancer in both men and women. Here are some indicators that nipple inversion could be cancer. It affects only one breast. It happens suddenly. “If you have any of these symptoms, see your physician right away,” says Mouabbi. Though flat and inverted nipples are typically harmless, sudden changes in the color or shape of your nipples could indicate an underlying health condition. If your nipples invert or change suddenly, let a healthcare provider know. “Inverted nipples are a normal variation in nipple shape and it’s usually not a concern,” Dr. Chen says. Up to 10% of the population are born with inverted nipples —a number that includes... Nipple retraction could be natural or a sign of aging, or it could signal an underlying condition. Learn what causes this symptom and when to see a doctor.