The mediastinum is a space in the thorax that contains a group of organs, vessels, nerves, lymphatics and their surrounding connective tissue. It lies in the midline of the chest between the pleura of each lung. It extends anterior to posterior fr... Mediastinum anatomy & function - superior, anterior, middle, inferior & posterior mediastinum cavity. Organs in the mediastinum . What are tumors in mediastinum mediastinum , the anatomic region located between the lungs that contains all the principal tissues and organs of the chest except the lungs. It extends from the sternum, or breastbone, back to the vertebral column and is bounded laterally by the pericardium, the membrane enclosing the heart, and the mediastinal pleurae, membranes that are continuous with those lining the thoracic cage. The mediastinum is a division of the thoracic cavity; it contains the heart, thymus gland, portions of the ...