Definition: Neuroticism refers to one of the “Big Five” personality traits, which is characterized by a tendency to experience negative emotions such as anxiety, depression, and fear. Neuroticism is the psychological trait of tending to experience negative emotions. What does this look like, and what makes some people more neurotic than others? Read on to find out. Neuroticism is one of the Big Five personality factors. Learn about what it means to have a neurotic personality and how this trait might impact your relationships. Neuroticism is a personality trait of being prone to negative emotions that don't interfere with daily function. Learn what it means, how to recognize it, and how to cope with it using mindfulness, thought replacement, and emotional intelligence.