Ondansetron Orally Disintegrating Tablets USP, 4 mgare white to off-white, round tablets debossed with ‘5’ on one side and ‘E’ on the other side with an embossed circular edge. Ondansetron ... Ondansetron is a medicine that blocks the actions of chemicals in the body that can trigger nausea and vomiting. It is used to prevent nausea and vomiting caused by surgery, cancer chemotherapy, or radiation treatment. Learn how to take it, what side effects to watch out for, and what interactions to avoid. 2.3 Administration Instructions for ZOFRAN ODT Orally Disintegrating Tablets Do not attempt to push ZOFRAN ODT tablets through the foil backing. With dry hands, PEEL BACK the foil backing of 1 blister and GENTLY remove the tablet. IMMEDIATELY place the ZOFRAN ODT tablet on top of the tongue where it will dissolve in seconds, then swallow with saliva. Administration with liquid is not necessary. Ondansetron is commonly available in tablet form and oral disintegrating tablets, providing convenient options for patients. The oral forms are typically administered before undergoing chemotherapy or radiation therapy, serving as a preemptive measure to mitigate the onset of nausea and vomiting associated with these treatments.