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Radiculopathy is a condition where a nerve root is compressed or damaged, causing pain, weakness or numbness in the affected area. Learn about the common causes, such as disk herniation, osteoarthritis or shingles, and how to diagnose and treat radiculopathy. Radiculopathy, or a pinched nerve of the spine, can cause pain in various parts of your body. Learn more about treating and preventing this condition. Radiculopathy is defined as a disorder involving the spinal nerve roots, often caused by age-related degenerative changes in the spine, such as spondylosis, or by trauma that affects nerve root alignment and function. AI generated definition based on: Encyclopedia of the Neurological Sciences (Second Edition), 2014 Radiculopathy occurs when nerve roots in the spine are compressed, leading to pain and weakness in the arms or legs, depending on the location.