Senescence: Cellular senescence is a process in which

Cellular senescence is a process in which cells cease dividing and undergo distinctive phenotypic alterations, including profound chromatin and secretome changes, and tumour-suppressor activation 1 – 6. Hayflick and Moorhead first introduced the term senescence to describe the phenomenon of irreversible growth arrest of human diploid cell strains after extensive serial passaging in culture 7. Later, this particular type of senescence (replicative senescence) was causally linked to telomere ... Senescence is a cellular response characterized by a stable growth arrest and other phenotypic alterations that include a proinflammatory secretome. Senescence plays roles in normal development, maintains tissue homeostasis, and limits tumor progression. However, senescence has also been implicated as a major cause of age-related disease. The meaning of SENESCENCE is the state of being old : the process of becoming old or aging. How to use senescence in a sentence. Did you know? Senescence is the gradual deterioration of functional characteristics in living organisms with age. Learn about the hallmarks, evolutionary and mechanistic theories of senescence, and the variation among species and organisms.