Sperm are male sex cells that fertilize female eggs to start pregnancy. Learn about sperm production, structure, health and problems that affect fertility. SPERM definition: 1. a sex cell produced by a man or male animal: 2. informal for semen (= the liquid produced by…. Learn more. Sperm, male reproductive cell, produced by most animals. In higher vertebrates, especially mammals, sperm are produced in the testes. The sperm unites with (fertilizes) the ovum (egg) of a female to produce a new offspring. Mature sperm have two distinguishable parts, a head and a tail. The meaning of SPERM is semen. How to use sperm in a sentence.