Learn about the physical signs of kidney disease, such as fatigue, trouble sleeping, dry skin, blood in urine, and more. Find out how to get tested and manage your kidney health with NKF resources and tips. Kidney failure symptoms can include itchiness, fatigue, and swelling. Symptoms become more severe in later stages but kidney failure also can happen suddenly. Learn how kidney issues can affect your energy, sleep, skin, muscles, breath, and more. See 10 common symptoms and what to do if you have them. The early stages of chronic kidney disease may not have symptoms, but kidney failure symptoms may include feeling sick, confusion, swelling and peeing a lot. What is kidney failure? Kidney failure (renal failure) means one or both of your kidneys no longer function well on their own.