To twitch is to make a very sudden, brief, unintentional movement. Your eye muscles might start to twitch when you're extremely tired. Twitch is a verb meaning to make a quick, jerky movement or to cause something to move in this way. It can also be a noun for a spasmodic movement or a sharp pain. Learn more about its origin, usage and related words. Definition of twitching in the Definitions.net dictionary. Meaning of twitching . What does twitching mean ? Information and translations of twitching in the most comprehensive dictionary definitions resource on the web.