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Antibiotics are used to treat typhoid fever and paratyphoid fever . Timely treatment can help prevent serious health problems. If you are sick, you can help protect others from getting sick too. Without treatment , typhoid fever and paratyphoid fever can last for about a month. Before widespread antibiotic use, the case fatality rate for typhoid fever was higher than 10%. Typhoid fever , also known as enteric fever , is a potentially fatal multisystemic illness caused primarily by Salmonella enterica, subspecies enterica serovar typhi and, to a lesser extent, related serovars paratyphi A, B, and C. The protean manifestations of typhoid fever make this disease a true diagnostic challenge. Learn about the most effective typhoid fever medication , including antibiotic options, dosage, and tips for managing symptoms and avoiding complications.